Fluorescence In Situ Hybridisation (FISH)
FISH is a targeted laboratory method that uses fluorescent DNA probes to detect selected chromosome or gene changes within cells. The probe set is chosen for a specific clinical question.
Common Clinical Uses
- Detecting selected gene rearrangements, amplifications, deletions, or changes in chromosome number.
- Supporting the classification of certain leukaemias, lymphomas, brain tumours, sarcomas, and solid tumours.
- Assessing biomarkers such as HER2 amplification or selected haematological rearrangements when clinically indicated.
Samples and Testing
Depending on the assay, testing may use formalin-fixed tumour tissue, blood, bone marrow, or another suitable specimen. Adequate cellularity and correct specimen handling are important for a reportable result.
Important Limitations
FISH examines only the regions targeted by the selected probes. A normal result does not exclude genetic changes outside those regions, and results must be interpreted with morphology, immunohistochemistry, and other molecular findings.
FISH Testing at Jaipur Molecular Lab
Contact our team with the clinical indication to confirm probe availability, specimen requirements, and the expected reporting timeline.
This information is for general education and does not replace medical advice. Test selection and interpretation should be discussed with a qualified clinician or pathologist.