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BRCA1 & BRCA2

What Is BRCA Testing?

BRCA testing involves a blood test designed to evaluate your genetic risk of developing certain cancers. The test looks for harmful mutations in the BRCA1 and BRCA2 genes, which are linked to an increased risk of breast, ovarian, and other cancers. Identifying mutations in these genes can help you understand your risk and make informed decisions about your health. This test Comprehensive BRCA1 & BRCA2 is available at Jaipur Molecular Lab.

Prevalence of BRCA-Related Cancers in India

By 2025, India is expected to report over 200,000 breast cancer cases and nearly 50,000 ovarian cancer cases. Familial breast cancer contributes to about 20-30% of all breast cancer cases, and BRCA1 and BRCA2 mutations are responsible for 7% of breast cancer and 15% of ovarian cancer cases in the country. These statistics emphasize the growing importance of genetic testing for early detection and prevention of these cancers.

Types of Cancers Linked to BRCA Mutations

Mutations in the BRCA1 and BRCA2 genes are associated with an increased risk of several cancers, including:

  • Breast cancer (affecting both men and women)
  • Ovarian cancer, including cancers of the fallopian tubes and primary peritoneal cancers
  • Prostate cancer
  • Pancreatic cancer
  • Melanoma

Cancer risks can vary slightly based on whether the mutation is in BRCA1 or BRCA2, but both genes are crucial in maintaining DNA integrity. Understanding these risks through BRCA testing helps assess the likelihood of developing these cancers, guiding preventive and treatment strategies.

Why Should You Consider BRCA Testing?

BRCA1 and BRCA2 mutations can significantly increase the risk of developing breast cancer and ovarian cancer. Here’s why you should consider BRCA testing:

  • Assessing hereditary cancer risk: If cancer runs in your family, BRCA testing helps you understand your genetic predisposition.
  • Guiding treatment decisions: Doctors can use your BRCA test results to recommend personalized treatment options, such as PARP inhibitors, for individuals diagnosed with cancer.
  • Enabling preventive measures: Early detection through BRCA testing offers the chance for preventive actions like surgery or lifestyle changes, reducing cancer risk.
  • Improving survival rates: Early detection and tailored treatment plans help increase the chances of successful treatment and long-term survival.

Who Should Get BRCA Tested?

If you have a family history or personal history of breast or ovarian cancer, you may be at higher risk for BRCA-related cancers. You should consider BRCA1 & BRCA2 testing at Jaipur Molecular Lab, if you meet any of these criteria:

  • Personal history of breast or ovarian cancer diagnosed at a young age (before menopause).
  • A family history of breast, ovarian, prostate, fallopian tube, peritoneal, or pancreatic cancer.
  • A male relative diagnosed with breast cancer.
  • A relative who carries a known BRCA1 or BRCA2 mutation.
  • Breast or ovarian cancer diagnosed before age 45.
  • A family member with bilateral breast cancer diagnosed under age 50.
  • Triple-negative breast cancer diagnosed before age 60, with or without a family history.
  • Two or more relatives diagnosed with ovarian cancer.
  • Ashkenazi Jewish ancestry, as this group has a higher prevalence of BRCA mutations.
  • Breast and ovarian cancers occurring in the same individual or family.

If any of these conditions apply to you, BRCA testing can provide critical information to assess your cancer risk and help you take the necessary steps to protect your health.

Infographic highlighting who should get a BRCA gene test, including personal and family history of breast or ovarian cancer, having a relative with a BRCA mutation, and Ashkenazi Jewish ancestry. Comprehensive BRCA1 & BRCA2 testing is available at Jaipur Molecular Lab.

Why Choose Jaipur Molecular Lab for BRCA Testing?

When it comes to BRCA testing, Jaipur Molecular Lab offers advanced, reliable, and comprehensive testing services. Here’s why you should choose us:

  • Next Generation Sequencing (NGS): We use the latest NGS technology to analyze DNA with high precision, ensuring the detection of a wide range of harmful mutations in the BRCA1 and BRCA2 genes.
  • Comprehensive mutation coverage: Our test covers all important mutations, including Single Nucleotide Variations (SNVs), Insertions and Deletions (InDels), structural variants, and copy number variations, providing a thorough analysis of your genetic risk.
  • High accuracy and sensitivity: Our test offers 100% coverage of the BRCA1 and BRCA2 genes, ensuring that SNVs and InDels are detected with the highest level of sensitivity and specificity.
  • Genetic counseling services: We offer complimentary pre-test and post-test genetic counseling to help you understand your results, the risks associated with them, and the best course of action for your health.

Final Thoughts

If you are concerned about your genetic risk for BRCA-related cancers, undergoing BRCA testing is a crucial step in managing your health. With BRCA testing from Jaipur Molecular Lab, you’ll receive accurate results backed by advanced technology and expert genetic counseling. This enables you to make informed decisions about cancer prevention, treatment, and overall health management, ensuring a healthier future.